Statistical issues in drug development (Record no. 37533)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02450nam a22003854a 4500 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615/.190727 |
| 100 1# - MAIN ENTRY--AUTHOR NAME | |
| Personal name | Senn, Stephen. |
| 245 10 - TITLE STATEMENT | |
| Title | Statistical issues in drug development |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 2nd ed. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication | Chichester, England ; |
| -- | Hoboken, NJ : |
| Name of publisher | John Wiley & Sons, |
| Year of publication | c2007. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Number of Pages | xix, 498 p. : |
| Other physical details | ill. |
| 490 1# - SERIES STATEMENT | |
| Series statement | Statistics in practice |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | A brief and superficial history of statistics for drug developers -- Design and interpretation of clinical trials as seen by a statistician -- Probability, Bayes, P-values, tests of hypotheses, and confidence intervals -- The work of the pharmaceutical statistician -- Allocating treatments to patients in clinical trials -- Baselines and covariate information -- |
| Formatted contents note | The measurement of treatment effects -- Demographic subgroups : representation and analysis -- Multiplicity -- Intention to treat, missing data and related matters -- One-sided and two-sided tests and other issues to do with significance and P-values -- Determining the sample size -- Multicentre trials -- Active control equivalence studies -- |
| Formatted contents note | Meta-analysis -- Cross-over trials -- n-of-1 trials -- Sequential trials -- Dose-finding -- Concerning pharmacokinetics and pharmacodynamics -- Bioequivalence studies -- Safety data, harms, drug monitoring, and pharmaco-epidemiology -- Pharmaco-economics and portfolio management -- Concerning pharmacogenetics, pharmacogenomics, and related matters. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical Term | Drug development |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://site.ebrary.com/lib/rucke/Doc?id=10232744 |
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