02019nam a2200337 a 4500 ebr10583403 CaPaEBR m u cr cn||||||||| 120224s2012 njua sb 001 0 eng d 2012007296 9781118188330 (cloth) 9781118028681 (cloth) 9781118354315 (e-book) CaPaEBR CaPaEBR (OCoLC)805560505 RM301.4 .S84 2012eb 615.7 23 Sugano, Kiyohiko. Biopharmaceutics modeling and simulations [electronic resource] : theory, practice, methods, and applications / Kiyohiko Sugano. Hoboken, N.J. : Wiley, c2012. xxxv, 483 p. : ill. Includes bibliographical references and index. Introduction -- Theoretical framework I : solubility -- Theoretical framework II : dissolution -- Theoretical framework III : biological membrane permeation -- Theoretical framework IV : gastrointestinal transit models and integration -- Physiology of gastrointestinal tract and other administration sites in humans and animals -- Drug parameters -- Validation of mechanistic models -- Bioequivalence and biopharmaceutical classification system -- Dose and particle size dependency -- Enabling formulations -- Food effect -- Biopharmaceutical modeling for miscellaneous cases -- Intestinal transporters -- Strategy in drug discovery and development -- Epistemology of biopharmaceutical modeling and good simulation practice. Electronic reproduction. Palo Alto, Calif. : ebrary, 2011. Available via World Wide Web. Access may be limited to ebrary affiliated libraries. Biopharmaceutics Simulation methods. Computer simulation. Electronic books. local ebrary, Inc. http://site.ebrary.com/lib/rucke/Doc?id=10583403 An electronic book accessible through the World Wide Web; click to view 185581 185581