02064nam a22003734a 4500 ebr10275622 CaPaEBR m u cr cn||||||||| 080527s2009 njua sb 001 0 eng 2008022807 101474921 DNLM 0470229640 (cloth) 9780470229644 (cloth) CaPaEBR CaPaEBR (OCoLC)317483524 RC677 .T87 2009eb 616.1/23061 22 Turner, J. Rick. Integrated cardiac safety [electronic resource] : assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance / J. Rick Turner, Todd A. Durham. Hoboken, N.J. : John Wiley & Sons, c2009. xxviii, 470 p. : ill. Includes bibliographical references (p. 397-455) and index. The importance of cardiac safety assessments -- The biological basis of adverse drug reactions -- Cardiac structure and function -- Cardiac pathophysiology and disease -- Drug discovery and drug design -- Nonclinical development -- The thorough QT/QTc trial -- General safety assessments -- Therapeutic use trials and meta-analyses -- Assessment methodologies in nonexperimental postmarketing surveillance -- Postmarketing proarrhythmic cardiac safety assessments -- Generalized cardiac safety -- Medication errors, adherence, and concordance -- Future directions in drug safety. Electronic reproduction. Palo Alto, Calif. : ebrary, 2013. Available via World Wide Web. Access may be limited to ebrary affiliated libraries. Cardiovascular toxicology. Heart Effect of drugs on. Drugs Side effects Testing. Drugs Safety measures. Electronic books. local Durham, Todd A. ebrary, Inc. http://site.ebrary.com/lib/rucke/Doc?id=10275622 An electronic book accessible through the World Wide Web; click to view 20835 20835