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  <titleInfo>
    <title>Enzyme-mediated resistance to antibiotics</title>
    <subTitle>mechanisms, dissemination, and prospects for inhibition</subTitle>
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  <name type="personal">
    <namePart>Bonomo, Robert A.</namePart>
  </name>
  <name type="personal">
    <namePart>Tolmasky, Marcelo.</namePart>
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  <name type="corporate">
    <namePart>ebrary, Inc</namePart>
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    <place>
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    <publisher>ASM Press</publisher>
    <dateIssued>c2007</dateIssued>
    <dateIssued encoding="marc">2007</dateIssued>
    <issuance>monographic</issuance>
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    <extent>xviii, 357 p., [8] p. of plates : ill. (some col.).</extent>
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  <tableOfContents>Overview of aminoglycosides and enzyme-mediated bacterial resistance: clinical implications / Robert A. Bonomo -- Aminoglycoside antibiotics / Kanchana Majumder ... [et al.] -- Structural aspects of aminoglycoside-modifying enzymes / Gerard D. Wright and Albert M. Berghuis -- Aminoglycoside-modifying enzymes: characteristics, localization, and dissemination / Marcelo E. Tolmasky -- rRNA methylases and resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone (MLSKO) antibiotics / Marilyn C. Roberts -- [Beta]-lactamases: historical perspectives / Karen Bush and Patricia A. Bradford -- Resistance mediated by penicillin-binding proteins / Malcolm G. P. Page -- Inhibition of class A [beta]-lactamases / Samy O. Meroueh, Jooyoung Cha, And Shahriar Mobashery -- Class B [beta]-lactamases / Gian Maria Rossolini and Jean-Denis Docquier -- Crystal structures of class C [beta]-lactamases: mechanistic implications and perspectives in drug design / C. Bauvois and J. Wouters --</tableOfContents>
  <tableOfContents>Class D [beta]-lactamases / Franck Danel, Malcolm G. P. Page, and David M. Livermore -- Kinetics of [beta]-lactamases and penicillin-binding proteins / Moreno Galleni and Jean-Marie Fr�ere -- The pharmaceutical industry and inhibitors of bacterial enzymes: implications for drug development / David M. Shlaes, Lefa Alksne, and Steven J. Projan -- [Beta]-lactamase inhibitory proteins / Zhen Zhang and Timothy Palzkill -- Active drug efflux in bacteria / J�urg Dreier -- Overview of dissemination mechanisms of genes coding for resistance to antibiotics / Marcelo E. Tolmasky -- Conjugative transposons / Louis B. Rice -- The dissemination of antibiotic resistance by bacterial conjugation / Virginia L. Waters -- Bacterial toxin-antitoxin systems as targets for the development of novel antibiotics / Juan C. Alonso ... [et al.] -- Integrons and superintegrons / Robert A. Bonomo, Andrea M. Hujer, and Kristine M. Hujer -- The biological cost of antibiotic resistance / Dan I. Andersson ... [et al.].</tableOfContents>
  <note type="statement of responsibility">editors, Robert A. Bonomo, Marcelo Tolmasky.</note>
  <note>Includes bibliographical references and index.</note>
  <note>Electronic reproduction. Palo Alto, Calif. : ebrary, 2013. Available via World Wide Web. Access may be limited to ebrary affiliated libraries.</note>
  <subject authority="lcsh">
    <topic>Drug resistance in microorganisms</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Drug resistance in microorganisms</topic>
    <topic>Genetic aspects</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Microbial enzymes</topic>
  </subject>
  <classification authority="lcc">QR177 .E59 2007eb</classification>
  <classification authority="ddc" edition="22">616.9/041</classification>
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