02450nam a22003854a 4500 ebr10232744 CaPaEBR m u cr cn||||||||| 071101s2007 enka sb 001 0 eng 2007045553 101319993 DNLM 9780470018774 (cloth : alk. paper) 0470018771 (cloth : alk. paper) CaPaEBR CaPaEBR (OCoLC)646751242 RM301.25 .S46 2007eb 615/.190727 22 Senn, Stephen. Statistical issues in drug development [electronic resource] / Stephen Senn. 2nd ed. Chichester, England ; Hoboken, NJ : John Wiley & Sons, c2007. xix, 498 p. : ill. Statistics in practice Includes bibliographical references and index. A brief and superficial history of statistics for drug developers -- Design and interpretation of clinical trials as seen by a statistician -- Probability, Bayes, P-values, tests of hypotheses, and confidence intervals -- The work of the pharmaceutical statistician -- Allocating treatments to patients in clinical trials -- Baselines and covariate information -- The measurement of treatment effects -- Demographic subgroups : representation and analysis -- Multiplicity -- Intention to treat, missing data and related matters -- One-sided and two-sided tests and other issues to do with significance and P-values -- Determining the sample size -- Multicentre trials -- Active control equivalence studies -- Meta-analysis -- Cross-over trials -- n-of-1 trials -- Sequential trials -- Dose-finding -- Concerning pharmacokinetics and pharmacodynamics -- Bioequivalence studies -- Safety data, harms, drug monitoring, and pharmaco-epidemiology -- Pharmaco-economics and portfolio management -- Concerning pharmacogenetics, pharmacogenomics, and related matters. Electronic reproduction. Palo Alto, Calif. : ebrary, 2013. Available via World Wide Web. Access may be limited to ebrary affiliated libraries. Drug development Statistical methods. Electronic books. local ebrary, Inc. Statistics in practice. http://site.ebrary.com/lib/rucke/Doc?id=10232744 An electronic book accessible through the World Wide Web; click to view 37533 37533