02437nam a2200385 a 4500 ebr10235163 CaPaEBR m u cr cn||||||||| 080709s2008 dcua sb 000 0 eng d 2008299448 9780309116688 0309116686 CaPaEBR CaPaEBR (OCoLC)560530759 n-us--- RC270.8 .I47 2008eb 362.196/994007 22 Improving the quality of cancer clinical trials [electronic resource] : workshop summary / National Cancer Policy Forum, Margie Patlack and Sharyl Nass, rapporteurs. Washington, D.C. : National Academies Press, c2008. xii, 124 p. : ill. (some col.). Includes bibliographical references. Introduction -- New clinical trial designs. Phase 0 trials -- Adaptive trial designs -- Targeting multiple pathways with multiple drugs -- Preclinical model systems -- Molecular imaging. Current and developing methods -- Challenges of molecular imaging -- Screening for predictive markers. The challenges of clinical validation -- Bioimaging predictive markers -- Clinical translation -- Panel discussion -- Costs of clinical trials. Regulatory costs -- Patient accrual -- Global outsourcing -- Time is money -- Public-private collaborations -- Regulatory issues. Regulatory barriers to innovation -- Patient advocacy perspective -- Regulation of in vitro diagnostics -- Regulatory issues in improving cancer clinical trials -- Reports from the case study discussion groups. Adaptive trial design -- Phase 0 trials -- Imaging -- Use of proteomics/genomics to assign therapy in lung cancer -- Use of genetics/genomics to assign therapy. Also available on the World Wide Web. Electronic reproduction. Palo Alto, Calif. : ebrary, 2013. Available via World Wide Web. Access may be limited to ebrary affiliated libraries. Cancer Treatment United States. Clinical trials. Electronic books. local Patlak, Margie. Nass, Sharyl J. National Cancer Policy Forum (U.S.) Institute of Medicine (U.S.) ebrary, Inc. http://site.ebrary.com/lib/rucke/Doc?id=10235163 An electronic book accessible through the World Wide Web; click to view 38707 38707