02437nam a2200385 a 4500001001200000003000800012006001900020007001500039008004100054010001700095020001800112020001500130040002100145035002100166043001200187050002500199082002300224245017300247260005800420300003700478504004100515505094000556530004201496533015201538650003801690650002101728655002901749700002001778700002001798710004001818710003301858710001701891856012601908999001702034ebr10235163CaPaEBRm        u        cr cn|||||||||080709s2008    dcua    sb    000 0 eng d  z  2008299448  z9780309116688  z0309116686  aCaPaEBRcCaPaEBR  a(OCoLC)560530759  an-us---14aRC270.8b.I47 2008eb04a362.196/99400722200aImproving the quality of cancer clinical trialsh[electronic resource] :bworkshop summary /cNational Cancer Policy Forum, Margie Patlack and Sharyl Nass, rapporteurs.  aWashington, D.C. :bNational Academies Press,cc2008.  axii, 124 p. :bill. (some col.).  aIncludes bibliographical references.0 aIntroduction -- New clinical trial designs. Phase 0 trials -- Adaptive trial designs -- Targeting multiple pathways with multiple drugs -- Preclinical model systems -- Molecular imaging. Current and developing methods -- Challenges of molecular imaging -- Screening for predictive markers. The challenges of clinical validation -- Bioimaging predictive markers -- Clinical translation -- Panel discussion -- Costs of clinical trials. Regulatory costs -- Patient accrual -- Global outsourcing -- Time is money -- Public-private collaborations -- Regulatory issues. Regulatory barriers to innovation -- Patient advocacy perspective -- Regulation of in vitro diagnostics -- Regulatory issues in improving cancer clinical trials -- Reports from the case study discussion groups. Adaptive trial design -- Phase 0 trials -- Imaging -- Use of proteomics/genomics to assign therapy in lung cancer -- Use of genetics/genomics to assign therapy.  aAlso available on the World Wide Web.  aElectronic reproduction.bPalo Alto, Calif. :cebrary,d2013.nAvailable via World Wide Web.nAccess may be limited to ebrary affiliated libraries. 0aCancerxTreatmentzUnited States. 0aClinical trials. 7aElectronic books.2local1 aPatlak, Margie.1 aNass, Sharyl J.2 aNational Cancer Policy Forum (U.S.)2 aInstitute of Medicine (U.S.)2 aebrary, Inc.40uhttp://site.ebrary.com/lib/rucke/Doc?id=10235163zAn electronic book accessible through the World Wide Web; click to view  c38707d38707