02031nam a22003254a 4500001001200000003000800012006001900020007001500039008004100054010001700095016002000112020002600132020002300158040002100181035002100202050002900223082001500252245009500267260004800362300005600410504005100466505080400517533015201321650002201473650001901495655002901514700001901543710001701562856012601579ebr10275759CaPaEBRm        u        cr cn|||||||||080703s2009    njuaf   sb    001 0 eng    z  20080296077 z1014781472DNLM  z9780470412893 (cloth)  z0470412895 (cloth)  aCaPaEBRcCaPaEBR  a(OCoLC)31744827114aRM301.3.G45bG457 2009eb04a615/.722200aGene family targeted molecular designh[electronic resource] /cedited by Karen E. Lackey.  aHoboken, N.J. :bJohn Wiley & Sons,cc2009.  axvi, 347 p., [16] p. of plates :bill. (some col.).  aIncludes bibliographical references and index.0 aDrug discoveries by gene family / Karen E. Lackey -- G-protein coupled receptors / Stephen L. Garland and Tom D. Heightman -- Ion channels gene family : strategies for discovering ion channel drugs / Maria L. Garcia and Gregory J. Kaczorowski -- Integrins / David D. Miller -- Strategies for discovering kinase drugs / Jerry L. Adams ... [et al.] -- Protease-directed drug discovery / Richard Sedrani, Ulrich Hommel, and Jo�rg Eder -- Small-molecule inhibitors of protein-protein interactions : challenges and prospects / Adrian Whitty -- Transporters / Anne Hersey, Frank E. Blaney, and Sandeep Modi -- Nuclear receptor drug discovery / Hiroyuki Kagechika and Aya Tanatani -- Summary and comparison of molecules designed to modulate druggable targets in the major gene families / Karen E. Lackey.  aElectronic reproduction.bPalo Alto, Calif. :cebrary,d2013.nAvailable via World Wide Web.nAccess may be limited to ebrary affiliated libraries. 0aPharmacogenomics. 0aDrugsxDesign. 7aElectronic books.2local1 aLackey, Karen.2 aebrary, Inc.40uhttp://site.ebrary.com/lib/rucke/Doc?id=10275759zAn electronic book accessible through the World Wide Web; click to view