02263nam a2200325 a 4500001001200000003000800012006001900020007001500039008004100054010001700095020002900112020002700141040002100168035002100189050002600210082001600236245011100252260003500363300005400398504005100452505036800503520064900871533015201520650004901672650002201721655002901743700002201772710001701794856012601811ebr10662545CaPaEBRm        u        cr cn|||||||||121024s2013    njuadf  sb    001 0 eng d  z  2012035755  z9781118065631 (hardback)  z9781118538180 (e-book)  aCaPaEBRcCaPaEBR  a(OCoLC)82886889214aRS419.5b.H542 2013eb04a615.1/922300aHigh-throughput screening methods in toxicity testingh[electronic resource] /cedited by Pablo Steinberg.  aHoboken, N.J. :bWiley,c2013.  axv, 552 p., [16] p. of plates :bill. (some col.)  aIncludes bibliographical references and index.0 apt. 1. General aspects -- pt. 2. High-throughput assays to assess different cytotoxicity endpoints -- pt. 3. High-throughput assays to assess DNA damage and carcinogenesis -- pt. 4. High-throughput assays to assess reproductive toxicity, cardiotoxicity, and haematotoxicity -- pt. 5. High-throughput assays to assess drug metabolism and receptor-related toxicity.  a"High-throughput assays are part of a paradigm shift, to more cost-effective and reliable methods, in the testing of chemical and drug safety. This book covers methods, data generation, data analysis, and applications in risk assessment for major toxicological assays to help toxicologists apply and understand the benefits and limits of high-throughput testing assays. Each chapter describes method principles and includes detailed information on data generation, data analysis, and applications in risk assessment. The topic is especially timely given Europe's REACH legislation and the US National Research Council"--cProvided by publisher.  aElectronic reproduction.bPalo Alto, Calif. :cebrary,d2013.nAvailable via World Wide Web.nAccess may be limited to ebrary affiliated libraries. 0aHigh throughput screening (Drug development) 0aToxicity testing. 7aElectronic books.2local1 aSteinberg, Pablo.2 aebrary, Inc.40uhttp://site.ebrary.com/lib/rucke/Doc?id=10662545zAn electronic book accessible through the World Wide Web; click to view