000			02019nam a2200337 a 4500
001			ebr10583403
003			CaPaEBR
006			m u
007			cr cn|||||||||
008			120224s2012 njua sb 001 0 eng d
010			_z 2012007296
020			_z9781118188330 (cloth)
020			_z9781118028681 (cloth)
020			_z9781118354315 (e-book)
040			_aCaPaEBR _cCaPaEBR
035			_a(OCoLC)805560505
050	1	4	_aRM301.4 _b.S84 2012eb
082	0	4	_a615.7 _223
100	1		_aSugano, Kiyohiko.
245	1	0	_aBiopharmaceutics modeling and simulations _h[electronic resource] : _btheory, practice, methods, and applications / _cKiyohiko Sugano.
260			_aHoboken, N.J. : _bWiley, _cc2012.
300			_axxxv, 483 p. : _bill.
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction -- Theoretical framework I : solubility -- Theoretical framework II : dissolution -- Theoretical framework III : biological membrane permeation -- Theoretical framework IV : gastrointestinal transit models and integration -- Physiology of gastrointestinal tract and other administration sites in humans and animals -- Drug parameters -- Validation of mechanistic models -- Bioequivalence and biopharmaceutical classification system -- Dose and particle size dependency -- Enabling formulations -- Food effect -- Biopharmaceutical modeling for miscellaneous cases -- Intestinal transporters -- Strategy in drug discovery and development -- Epistemology of biopharmaceutical modeling and good simulation practice.
533			_aElectronic reproduction. _bPalo Alto, Calif. : _cebrary, _d2011. _nAvailable via World Wide Web. _nAccess may be limited to ebrary affiliated libraries.
650		0	_aBiopharmaceutics _xSimulation methods.
650		0	_aComputer simulation.
655		7	_aElectronic books. _2local
710	2		_aebrary, Inc.
856	4	0	_uhttp://site.ebrary.com/lib/rucke/Doc?id=10583403 _zAn electronic book accessible through the World Wide Web; click to view
999			_c185581 _d185581